Introduction
Anxiolytic is the name given to those compounds which ar legal in alleviating the symptoms of anxiety.
Anxiolytics were formally known as Minor Tranquilisers or Sedatives.
Today, Benzodiazepines are the most widely used Anxiolytic medications, however, in the beginning their introduction Barbiturates and Bromides were commonly used.
The Barbiturates were first used in the earlier 20th century. They, along with the Bromides, were widely used in the intervention of anxiety states before the introduction of Meprobamate (Equinil) and then the Benzodiazepines.
Today, Barbiturates are considered unsuitable for continuing therapy in the treatment of anxiety because of their addiction potential, profound sedative effect and the fact that they interact with a considerable number of drugs. Their use today is mainly dependant to the treatment of convulsive disorders and as Induction Agents in anaesthesia.
memorial of Benzodiazepines
Benzodiazepines were disc all overed in 1954 by Dr Leo Sternbach, an Austrian pharmacist working for the pharmaceutical company Hoffman-La Roche. La Roche Laboratories submitted the drug for pharmacological evaluation and its superiority to other link drugs was discovered.
The first Benzodiazepine was patent in 1959, and in 1960 it was introduced to the world as Chlordiazepoxide (Librium). elicit in the drugs capabilities sparked continued testing of related compounds which eventually led to the introduction of Diazepam (Valium) in 1963.
The necessitate of Benzodiazepines has continued to lead to the release of many other Benzodiazepine derivatives including Nitrazepam (Mogadon) in 1965, Flurazepam (Dalmane) in 1973 and Alprazolam (Xanax) in the 1980s.
By the mid-1970s, over 8,000 tonnes of Benzodiazepines were sold every year.
Currently, over 2,000 different Benzodiazepines have been synthesised, with more than than three dozen Benzodiazepine derivatives available on the market....If you want to flap a full essay, order it on our website: Orderessay
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